Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist, also referred to as an incretin mimetic. GLP-1 agonists were initially developed to improve glycemic control in type 2 diabetics as in adjunct to diet and exercise. It works to enhance the growth of beta cells in the pancreas, which are sites of insulin production. Semaglutide will delay gastric emptying by reducing glucagon secretion in a glucose-dependent manner. The delay in gastric emptying can reduce appetite, improve control of eating, and reduce cravings. Semaglutide offers glycemic control with improvement to HbA1c levels, moderate weight loss and a significant reduction in risk of major adverse cardiac events as evaluated in a 2-year cardiovascular outcomes trial vs. placebo.
Most people have some degree of insulin resistance whether they realize it or not.
Does Metformin suppress appetite?
- As a whole, metformin does suppress appetite. Apart form known glucose-lowering effects, metformin also has multiple benefits for health, including lowering hunger which leads to lower calorie intake and inhibition of unfavorable fat storage in adipose tissues.
Nausea, vomiting and diarrhea are some of the most common side effects people have when they first start taking metformin. These problems usually go away over time. You can reduce these effects by taking metformin with a meal at night.
The most common side effects of the Semaglutide injection include:
- Stomach (abdominal ) pain
- Burping, gases, bloating in the stomach
- Upset stomach, heartburn
Due to these possible side effects, it is recommended to take a pharmaceutical grade probiotic.